HDGFL3

Across TCGA patient cohorts, HDGFL3 mutation is significantly associated with the RNA expression of many other genes, with 507 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDGFL3-associated genes across cancer lineages are IGHD2-2, SFPQP1, and PSMD12P1. Each is linked with HDGFL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDGFL3-to-partner and partner-to-HDGFL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD2-2 grouped by HDGFL3-low versus HDGFL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGFL3→partner) and Y-score (partner→HDGFL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD2-2 →	+1.072	+2.012	.009	.005	3	2
UCEC	SFPQP1 →	+0.045	+2.378	<.001	.002	3	2
UCEC	PSMD12P1 →	+0.142	+2.914	.004	.001	3	2
UCEC	PGAM1P13 →	+0.041	+2.899	.005	.003	3	2
UCEC	RNA5SP461 →	+0.224	+4.253	<.001	.004	3	2
UCEC	RNA5SP415 →	+0.545	+2.351	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 507 associations by consensus.

IGHD2-2 by HDGFL3 expression — UCEC

Explore this box plot interactively →