HDGFL2

Across TCGA patient cohorts, HDGFL2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,364 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HDGFL2-associated genes across cancer lineages are PLAUR, MTERF2, and MMP19. Each is linked with HDGFL2 in more than 5 cancer types. Because this analysis shows association rather than direction, both HDGFL2-to-partner and partner-to-HDGFL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDGFL2 versus PLAUR in GBM, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGFL2→partner) and Y-score (partner→HDGFL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLAUR →	-0.881	-0.272	<.001	<.001	3	6
BRCA	MTERF2 →	+0.634	+0.323	<.001	<.001	3	6
GBM	MMP19 →	-1.153	-0.309	<.001	<.001	3	6
LSCC	ZNF557 →	+0.627	+0.294	<.001	<.001	3	6
LSCC	POGZ →	+0.672	+0.282	<.001	.001	3	6
HNSC	SAFB →	+0.587	+0.234	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,364 associations by consensus.

HDGFL2 vs PLAUR — GBM

Explore this scatter interactively →