HDGFL2

Across TCGA pan-cancer cohorts, HDGFL2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HDGFL2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HDGFL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HDGFL2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LIHC, and KIRP are the cancer types where HDGFL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HDGFL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.991	<.001	10	view →
LIHC	Female	II,III,IV	+1.397	<.001	9	view →
KIRP	All	II,III,IV	+0.540	.001	8	view →
STAD	Male	II,III,IV	+0.980	<.001	6	view →
LUSC	Male	II,III,IV	+0.798	<.001	5	view →
COAD	All	II,III,IV	+0.280	<.001	5	view →
THCA	All	All	+0.236	<.001	5	view →
BLCA	All	All	+0.447	.015	4	view →
BRCA	All	All	+0.324	.002	4	view →
CHOL	All	All	+1.927	<.001	3	view →
ESCA	Female	All	+1.206	<.001	3	view →
KIRC	All	All	+0.227	.014	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HDGFL2–HNSC

Open the HNSC breakdown →