HDGFL2

Across TCGA patient cohorts, HDGFL2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDGFL2-associated genes across cancer lineages are Annexin-1, ATM, and C-Raf. Each is linked with HDGFL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDGFL2-to-partner and partner-to-HDGFL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by HDGFL2-low versus HDGFL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGFL2→partner) and Y-score (partner→HDGFL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.461	+2.000	.015	.029	3	2
UCEC	ATM →	-0.662	-3.794	<.001	<.001	3	2
UCEC	C-Raf →	+0.165	+1.925	.001	.005	3	2
UCEC	14-3-3_beta →	-0.101	-3.673	.005	.001	3	1
UCEC	ERK2 →	+0.146	+1.584	.036	.019	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.337	+1.584	.028	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Annexin-1 by HDGFL2 expression — UCEC

Explore this box plot interactively →