HDGFL2

Across TCGA cell cohorts, HDGFL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,920 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HDGFL2-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of anaphase-promoting complex-dependent catabolic process, and Regulation of protein localization to chromatin. Each is linked with HDGFL2 in more than 19 cancer types. Because this analysis shows association rather than direction, both HDGFL2-to-partner and partner-to-HDGFL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by HDGFL2-low versus HDGFL2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGFL2→partner) and Y-score (partner→HDGFL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.166	+0.852	<.001	<.001	3	20
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.171	+0.787	<.001	<.001	3	19
BONE	Regulation of protein localization to chromatin →	+0.172	+0.714	<.001	<.001	3	18
LIVER	Negative regulation of protein localization to chromatin →	+0.152	+1.016	<.001	<.001	3	17
PANCREAS	U2-type prespliceosome assembly →	+0.103	+0.666	<.001	<.001	3	17
BONE	Negative regulation of chromosome organization →	+0.088	+0.584	.006	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,920 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by HDGFL2 expression — LUNG_SCLC

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