HDGFL1

Across TCGA cell cohorts, HDGFL1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDGFL1-associated genes across cancer lineages are GPRC6A, VN1R4, and OR4M2. Each is linked with HDGFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDGFL1-to-partner and partner-to-HDGFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPRC6A grouped by HDGFL1-low versus HDGFL1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDGFL1→partner) and Y-score (partner→HDGFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GPRC6A →	+0.020	+4.169	<.001	.008	3	1
CNS	VN1R4 →	+0.073	+4.754	<.001	.005	3	1
CNS	OR4M2 →	+0.142	+5.044	<.001	.001	3	1
LARGE_INTESTINE	FAM170A →	+0.092	+3.392	<.001	.001	3	1
LARGE_INTESTINE	OR4F15 →	+0.011	+3.240	<.001	.004	3	1
LARGE_INTESTINE	ZFP57 →	+1.056	+3.482	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GPRC6A by HDGFL1 expression — CNS

Explore this box plot interactively →