HDAC9

Across TCGA pan-cancer cohorts, HDAC9 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HDAC9 data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher HDAC9 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HDAC9 expression acts as an unfavorable survival marker.

GBM, PDAC, and LSCC are the cancer types where HDAC9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.266	0.563	.013	4	view →
PDAC	OS	Median	IV	0.293	0.943	.038	3	view →
LSCC	DFS	Median	II,III,IV	0.716	1.000	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HDAC9–GBM (OS)

Open the GBM breakdown →