HDAC8

Across TCGA pan-cancer cohorts, HDAC8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HDAC8 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HDAC8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HDAC8 expression acts as an unfavorable survival marker.

KIRP, BLCA, and UCEC are the cancer types where HDAC8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.161	0.771	.002	21	view →
BLCA	OS	Median	IV	0.153	0.589	.030	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HDAC8–KIRP (OS)

Open the KIRP breakdown →