HDAC8

Across TCGA pan-cancer cohorts, HDAC8 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HDAC8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HDAC8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HDAC8 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where HDAC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HDAC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.697	<.001	12	view →
COAD	Male	IV	+0.915	<.001	11	view →
BLCA	All	All	+0.579	<.001	11	view →
LIHC	Female	II,III,IV	+0.922	<.001	9	view →
STAD	Male	II,III,IV	+0.743	<.001	8	view →
LUAD	Female	All	+0.352	<.001	8	view →
KICH	Female	All	−0.509	<.001	6	view →
BRCA	All	All	+0.352	<.001	6	view →
UCEC	All	II,III,IV	+0.461	.021	4	view →
CHOL	All	All	+1.344	<.001	3	view →
READ	All	All	+0.802	<.001	3	view →
LUSC	All	All	+0.248	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

HDAC8–HNSC

Open the HNSC breakdown →