HDAC8

Across TCGA patient cohorts, HDAC8 RNA expression is significantly associated with the RNA expression of many other genes, with 19,945 significant associations in total. UVM shows the largest number of these associations.

The most reproducible HDAC8-associated genes across cancer lineages are NONO, NKAP, and VBP1. Each is linked with HDAC8 in more than 32 cancer types. Because this analysis shows association rather than direction, both HDAC8-to-partner and partner-to-HDAC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC8 versus NONO in CHOL, with a Pearson correlation of 0.51.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC8→partner) and Y-score (partner→HDAC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	NONO →	+1.095	+0.602	<.001	<.001	3	33
UVM	NKAP →	+1.124	+0.867	<.001	<.001	3	33
UVM	VBP1 →	+1.247	+0.913	<.001	<.001	3	32
TGCT	RBM10 →	+0.605	+0.721	<.001	<.001	3	32
UVM	POLA1 →	+1.276	+0.708	<.001	<.001	3	32
ACC	UPRT →	+1.019	+0.741	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,945 associations by consensus.

HDAC8 vs NONO — CHOL

Explore this scatter interactively →