HDAC8

Across TCGA patient cohorts, HDAC8 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,394 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HDAC8-associated proteins across cancer lineages are HTATSF1, ATRX, and RPL26. Each is linked with HDAC8 in more than 5 cancer types. Because this analysis shows association rather than direction, both HDAC8-to-partner and partner-to-HDAC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC8 versus HTATSF1 in GBM, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC8→partner) and Y-score (partner→HDAC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HTATSF1 →	+0.306	+0.310	.001	<.001	3	6
LSCC	ATRX →	+0.331	+0.444	<.001	<.001	3	6
GBM	RPL26 →	-0.624	-0.353	.001	.001	3	5
GBM	TCEAL4 →	+0.445	+0.411	<.001	<.001	3	5
BRCA	S100A8 →	-1.508	-0.304	<.001	<.001	3	4
BRCA	S100A9 →	-1.359	-0.272	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,394 associations by consensus.

HDAC8 vs HTATSF1 — GBM

Explore this scatter interactively →