HDAC8

Across TCGA patient cohorts, HDAC8 mutation is significantly associated with the RNA expression of many other genes, with 2,843 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC8-associated genes across cancer lineages are RNU1-17P, RNU4-9P, and NR1H5P. Each is linked with HDAC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC8-to-partner and partner-to-HDAC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by HDAC8-low versus HDAC8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC8→partner) and Y-score (partner→HDAC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU1-17P →	+0.257	+6.734	<.001	<.001	3	3
COAD	RNU4-9P →	+0.613	+4.602	<.001	.008	3	2
COAD	NR1H5P →	+0.176	+5.721	<.001	.001	3	2
COAD	RNU7-196P →	+0.904	+5.003	<.001	.004	3	2
COAD	LINC01386 →	+0.176	+4.516	<.001	.009	3	2
CESC	VN1R6P →	+0.034	+4.559	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,843 associations by consensus.

RNU1-17P by HDAC8 expression — COAD

Explore this box plot interactively →