HDAC8

Across TCGA patient cohorts, HDAC8 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC8-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1068, and eIF4E. Each is linked with HDAC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC8-to-partner and partner-to-HDAC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by HDAC8-low versus HDAC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC8→partner) and Y-score (partner→HDAC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.118	-1.680	.028	.042	3	2
UCEC	EGFR_pY1068 →	-0.208	-1.584	.021	.019	3	1
UCEC	eIF4E →	+0.160	+2.335	.035	.018	3	1
UCEC	A-Raf_pS299 →	-0.172	-2.502	<.001	.001	3	1
UCEC	Gab2 →	+0.381	+3.169	.002	.018	3	1
UCEC	JNK2 →	+0.224	+2.486	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

mTOR_pS2448 by HDAC8 expression — UCEC

Explore this box plot interactively →