HDAC8

Across TCGA cell cohorts, HDAC8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,752 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HDAC8-associated GO terms across cancer lineages are Sex-chromosome dosage compensation, Negative regulation of maintenance of sister chromatid cohesion, and Negative regulation of maintenance of mitotic sister chromatid cohesion. Each is linked with HDAC8 in more than 10 cancer types. Because this analysis shows association rather than direction, both HDAC8-to-partner and partner-to-HDAC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sex-chromosome dosage compensation grouped by HDAC8-low versus HDAC8-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC8→partner) and Y-score (partner→HDAC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Sex-chromosome dosage compensation →	+0.080	+0.607	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Negative regulation of maintenance of sister chromatid cohesion →	+0.173	+1.038	.001	.001	3	9
LUNG_NSCLC_LUSC	Negative regulation of maintenance of mitotic sister chromatid cohesion →	+0.173	+1.038	.001	.001	3	9
LARGE_INTESTINE	Dosage compensation by inactivation of X chromosome →	+0.066	+0.490	<.001	.001	2	10
LUNG_SCLC	Negative regulation of protein modification by small protein conjugation or removal →	+0.052	+0.355	.002	.002	2	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.156	+0.593	.001	.006	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,752 associations by consensus.

Sex-chromosome dosage compensation by HDAC8 expression — OVARY

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