HDAC3

Across TCGA pan-cancer cohorts, HDAC3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HDAC3 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HDAC3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HDAC3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where HDAC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.467	0.797	.006	24	view →
LSCC	OS	Median	All	0.909	0.714	.002	17	view →
CCRCC	OS	Tertile	III,IV	0.395	0.828	.014	17	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HDAC3–HNSC (DFS)

Open the HNSC breakdown →