HDAC3

Across TCGA pan-cancer cohorts, HDAC3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HDAC3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HDAC3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HDAC3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where HDAC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HDAC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.742	<.001	12	view →
COAD	Female	II,III,IV	+0.638	<.001	11	view →
HNSC	All	IV	+0.525	<.001	11	view →
LIHC	Female	II,III,IV	+0.982	<.001	8	view →
LUAD	Male	All	+0.410	<.001	8	view →
THCA	All	All	−0.321	<.001	7	view →
BLCA	All	All	+0.479	.006	6	view →
LUSC	Female	All	+0.457	<.001	6	view →
CHOL	Female	All	+1.670	<.001	5	view →
KICH	Female	All	−0.960	<.001	5	view →
READ	All	II,III,IV	+0.540	<.001	4	view →
STAD	All	II,III,IV	+0.450	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HDAC3–KIRC

Open the KIRC breakdown →