HDAC3

Across TCGA patient cohorts, HDAC3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,817 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HDAC3-associated genes across cancer lineages are FBXL20, BRD8, and PELP1. Each is linked with HDAC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HDAC3-to-partner and partner-to-HDAC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC3 versus FBXL20 in HNSC, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC3→partner) and Y-score (partner→HDAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FBXL20 →	+0.559	+0.164	.001	.002	3	5
HNSC	BRD8 →	+0.464	+0.154	<.001	.004	3	5
LSCC	PELP1 →	+0.597	+0.218	<.001	<.001	3	5
LSCC	C12orf45 →	+0.546	+0.228	<.001	<.001	3	5
LSCC	HIBCH →	+0.543	+0.244	<.001	<.001	3	5
HNSC	PRR3 →	+0.501	+0.151	.005	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,817 associations by consensus.

HDAC3 vs FBXL20 — HNSC

Explore this scatter interactively →