HDAC3

Across TCGA patient cohorts, HDAC3 mutation is significantly associated with the RNA expression of many other genes, with 930 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC3-associated genes across cancer lineages are BNIP3P41, NDUFA5P9, and DNAJA1P1. Each is linked with HDAC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC3-to-partner and partner-to-HDAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P41 grouped by HDAC3-low versus HDAC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC3→partner) and Y-score (partner→HDAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3P41 →	+0.010	+4.019	<.001	.005	3	3
CESC	NDUFA5P9 →	+0.070	+5.579	<.001	.001	3	2
CESC	DNAJA1P1 →	+0.043	+4.891	<.001	<.001	3	2
UCEC	LINC00869 →	-0.590	-2.257	<.001	.001	3	2
UCEC	SCD →	+0.689	+3.480	.005	.002	3	2
UCEC	ZNF133 →	-0.417	-1.883	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 930 associations by consensus.

BNIP3P41 by HDAC3 expression — UCEC

Explore this box plot interactively →