HDAC3

Across TCGA patient cohorts, HDAC3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC3-associated genes across cancer lineages are PCNA, Caspase-8, and eEF2. Each is linked with HDAC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC3-to-partner and partner-to-HDAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by HDAC3-low versus HDAC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC3→partner) and Y-score (partner→HDAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.167	+2.584	.049	.010	3	2
UCEC	Caspase-8 →	-0.213	-3.432	.031	.005	3	2
UCEC	eEF2 →	+0.366	+2.502	.009	.002	3	1
UCEC	ERK2 →	+0.217	+2.906	.004	.001	3	1
UCEC	ETS-1 →	+0.282	+2.700	.023	.006	3	1
UCEC	GAPDH →	+0.482	+3.169	.022	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PCNA by HDAC3 expression — UCEC

Explore this box plot interactively →