HDAC3

Across TCGA cell cohorts, HDAC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,120 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDAC3-associated GO terms across cancer lineages are Microtubule organizing center organization, Microtubule polymerization, and Nuclear export. Each is linked with HDAC3 in more than 15 cancer types. Because this analysis shows association rather than direction, both HDAC3-to-partner and partner-to-HDAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule organizing center organization grouped by HDAC3-low versus HDAC3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC3→partner) and Y-score (partner→HDAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.122	+0.927	<.001	<.001	3	16
BREAST	Microtubule polymerization →	+0.110	+0.748	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.086	+0.915	.001	<.001	3	16
PANCREAS	Protein import into nucleus →	+0.093	+0.673	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.123	+1.016	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.151	+1.075	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,120 associations by consensus.

Microtubule organizing center organization by HDAC3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →