HDAC3

Across TCGA cell cohorts, HDAC3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HDAC3-associated genes across cancer lineages are CD300H, PTH, and SPATA31D1. Each is linked with HDAC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC3-to-partner and partner-to-HDAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300H grouped by HDAC3-low versus HDAC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC3→partner) and Y-score (partner→HDAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CD300H →	+0.033	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	PTH →	+0.027	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.028	+5.228	<.001	.005	3	1
BLOOD_Lymphoma	REG3G →	+0.044	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	IFNL3 →	+0.142	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CD300H by HDAC3 expression — LARGE_INTESTINE

Explore this box plot interactively →