HDAC3

Across TCGA cell cohorts, HDAC3 mutation is significantly associated with the mutation status of many other genes, with 1,059 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDAC3-associated genes across cancer lineages are G3BP2, DOK5, and FPGS. Each is linked with HDAC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC3-to-partner and partner-to-HDAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G3BP2 grouped by HDAC3-low versus HDAC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC3→partner) and Y-score (partner→HDAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	G3BP2 →	+3.350	+4.584	.003	.003	1	3
BLOOD_Lymphoma	DOK5 →	+5.014	+5.584	.003	.003	1	3
LUNG_NSCLC_LUAD	FPGS →	+4.772	+5.339	.004	.004	1	3
BLOOD_Lymphoma	FOXE3 →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	QRICH1 →	+6.014	+6.014	.001	.001	1	3
LUNG_NSCLC_LUAD	RNASE3 →	+5.772	+5.772	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,059 associations by consensus.

G3BP2 by HDAC3 expression — LARGE_INTESTINE

Explore this box plot interactively →