HDAC2

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, HDAC2 mutation is significantly associated with the RNA expression of many other genes, with 1,616 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC2-associated genes across cancer lineages are KRTAP20-3, HMGB1P9, and MIR1252. Each is linked with HDAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC2-to-partner and partner-to-HDAC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC2→partner) and Y-score (partner→HDAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECKRTAP20-3 →+0.059+4.060<.001.00632
UCECHMGB1P9 →+0.118+2.420.009<.00132
CESCMIR1252 →+0.639+4.669<.001.00732
UCECVTRNA2-2P →+0.535+2.467<.001<.00132
UCECRNU6-1213P →+0.190+3.555<.001.00232
HNSCRPL17P19 →+0.083+5.912.005.00232
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,616 associations by consensus.

Exploration