HDAC1

Across TCGA pan-cancer cohorts, HDAC1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HDAC1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HDAC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HDAC1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where HDAC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.920	0.733	.002	16	view →
UCEC	OS	Quartile	II,III,IV	0.389	1.000	.032	12	view →
CCRCC	OS	Tertile	All	0.907	1.000	.020	6	view →
LUAD	OS	Median	All	0.910	0.765	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HDAC1–LSCC (OS)

Open the LSCC breakdown →