HDAC1

Across TCGA patient cohorts, HDAC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,798 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HDAC1-associated proteins across cancer lineages are KHDRBS1, RCC2, and PPP1R8. Each is linked with HDAC1 in more than 7 cancer types. Because this analysis shows association rather than direction, both HDAC1-to-partner and partner-to-HDAC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC1 versus KHDRBS1 in GBM, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC1→partner) and Y-score (partner→HDAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KHDRBS1 →	+0.209	+0.246	<.001	<.001	3	8
GBM	RCC2 →	+0.351	+0.249	<.001	<.001	3	7
GBM	PPP1R8 →	+0.202	+0.312	<.001	<.001	3	6
GBM	YTHDF2 →	+0.249	+0.211	<.001	<.001	3	6
GBM	NASP →	+0.492	+0.221	<.001	.007	3	6
BRCA	HNRNPF →	+0.290	+0.464	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,798 associations by consensus.

HDAC1 vs KHDRBS1 — GBM

Explore this scatter interactively →