HDAC1

Across TCGA patient cohorts, HDAC1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,057 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HDAC1-associated genes across cancer lineages are SFRP2, LPAR4, and RAVER2. Each is linked with HDAC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HDAC1-to-partner and partner-to-HDAC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC1 versus SFRP2 in OV, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC1→partner) and Y-score (partner→HDAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SFRP2 →	-2.726	-0.330	<.001	.001	3	6
GBM	LPAR4 →	-0.839	-0.354	.003	<.001	3	6
BRCA	RAVER2 →	+0.764	+0.241	.003	.003	3	6
OV	COL5A2 →	-1.196	-0.290	.007	.003	3	6
OV	FAP →	-1.488	-0.284	.002	.003	3	6
OV	CCDC80 →	-1.389	-0.417	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,057 associations by consensus.

HDAC1 vs SFRP2 — OV

Explore this scatter interactively →