HDAC1

Across TCGA cell cohorts, HDAC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,735 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDAC1-associated GO terms across cancer lineages are Hair follicle placode formation, Mitotic chromosome condensation, and Mitotic nuclear division. Each is linked with HDAC1 in more than 18 cancer types. Because this analysis shows association rather than direction, both HDAC1-to-partner and partner-to-HDAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hair follicle placode formation grouped by HDAC1-low versus HDAC1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC1→partner) and Y-score (partner→HDAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Hair follicle placode formation →	+0.104	+1.369	<.001	<.001	3	19
BONE	Mitotic chromosome condensation →	+0.135	+0.829	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Mitotic nuclear division →	+0.103	+0.868	.002	.008	3	13
BLOOD_Myeloma	Mitotic spindle organization →	+0.063	+0.759	.006	<.001	3	12
BONE	Sister chromatid segregation →	+0.142	+0.885	.002	.003	3	12
BREAST	Negative regulation of RNA splicing →	+0.086	+0.736	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,735 associations by consensus.

Hair follicle placode formation by HDAC1 expression — SOFT_TISSUE

Explore this box plot interactively →