HCST

Across TCGA patient cohorts, HCST protein abundance is significantly associated with the protein abundance of many other proteins, with 18,753 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCST-associated proteins across cancer lineages are TNS3, TNS3_S1154, and NDUFA3. Each is linked with HCST in more than 6 cancer types. Because this analysis shows association rather than direction, both HCST-to-partner and partner-to-HCST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCST versus TNS3 in BRCA, with a Pearson correlation of 0.66.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HCST→partner) and Y-score (partner→HCST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS3 →	+0.756	+1.051	<.001	<.001	3	7
CCRCC	TNS3_S1154 →	+0.987	+0.783	.008	.001	2	6
PDAC	NDUFA3 →	-0.333	-0.242	<.001	.001	3	4
BRCA	TNS3_S953 →	+1.493	+1.075	<.001	.001	3	4
GBM	RCN3 →	+0.788	+0.429	<.001	<.001	3	4
GBM	ATP5F1B →	-0.268	-0.558	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,753 associations by consensus.

HCST vs TNS3 — BRCA

Explore this scatter interactively →