HCRTR2

Across TCGA patient cohorts, HCRTR2 mutation is significantly associated with the RNA expression of many other genes, with 4,577 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCRTR2-associated genes across cancer lineages are WFDC21P, KPNA2, and CDCA2. Each is linked with HCRTR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCRTR2-to-partner and partner-to-HCRTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC21P grouped by HCRTR2-low versus HCRTR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCRTR2→partner) and Y-score (partner→HCRTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WFDC21P →	-0.972	-3.079	.001	<.001	3	3
UCEC	KPNA2 →	+0.578	+2.137	.005	.001	3	3
UCEC	CDCA2 →	+0.928	+3.000	<.001	<.001	3	3
UCEC	ERCC6L →	+0.726	+2.523	<.001	<.001	3	3
UCEC	RNU6-23P →	+0.270	+1.719	<.001	.006	3	3
UCEC	SEC14L6 →	-0.675	-2.126	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,577 associations by consensus.

WFDC21P by HCRTR2 expression — UCEC

Explore this box plot interactively →