HCRTR2

Across TCGA cell cohorts, HCRTR2 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCRTR2-associated genes across cancer lineages are GPR26, C10orf71, and OR10G3. Each is linked with HCRTR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCRTR2-to-partner and partner-to-HCRTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR26 grouped by HCRTR2-low versus HCRTR2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCRTR2→partner) and Y-score (partner→HCRTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR26 →	+0.036	+4.906	<.001	.006	3	1
OESOPHAGUS	C10orf71 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Leukemia	OR10G3 →	+0.025	+5.201	<.001	.006	3	1
BLOOD_Leukemia	C14orf177 →	+0.100	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR1P1 →	+0.189	+4.922	<.001	.009	3	1
LUNG_NSCLC_LUAD	PMIS2 →	+0.038	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

GPR26 by HCRTR2 expression — OESOPHAGUS

Explore this box plot interactively →