HCRTR1

Across TCGA pan-cancer cohorts, HCRTR1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HCRTR1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HCRTR1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HCRTR1 expression acts as an unfavorable survival marker.

COAD, BLCA, and UCEC are the cancer types where HCRTR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.239	0.791	.014	6	view →
BLCA	DFS	Median	IV	0.147	0.479	.026	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	DFS	Median	All	0.096	0.526	.023	6	view →
BRCA	DFS	Median	All	0.128	0.527	.002	4	view →
GBM	OS	Median	All	0.200	0.416	.036	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUAD	DFS	Median	All	0.049	0.814	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HCRTR1–COAD (OS)

Open the COAD breakdown →