HCRTR1

Across TCGA pan-cancer cohorts, HCRTR1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of HCRTR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HCRTR1 RNA is repressed in tumor relative to normal tissue. In most cancer types HCRTR1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where HCRTR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HCRTR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.162	<.001	12	view →
THCA	All	II,III,IV	−0.415	<.001	9	view →
KICH	All	All	−0.265	<.001	7	view →
BRCA	All	III,IV	−0.296	<.001	6	view →
UCEC	All	III,IV	−0.192	.001	6	view →
KIRP	Male	All	−0.152	<.001	6	view →
LUAD	Male	III,IV	−0.141	.007	3	view →
BLCA	Female	All	+0.115	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

HCRTR1–KIRC

Open the KIRC breakdown →