HCRTR1

Across TCGA patient cohorts, HCRTR1 mutation is significantly associated with the RNA expression of many other genes, with 405 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCRTR1-associated genes across cancer lineages are TUBB4BP4, SPRING1P1, and RPS3AP46. Each is linked with HCRTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCRTR1-to-partner and partner-to-HCRTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB4BP4 grouped by HCRTR1-low versus HCRTR1-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCRTR1→partner) and Y-score (partner→HCRTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TUBB4BP4 →	+0.206	+7.209	<.001	<.001	3	2
BRCA	SPRING1P1 →	+0.073	+5.639	<.001	.002	3	2
UCEC	RPS3AP46 →	+0.161	+2.241	.008	.002	3	2
UCEC	LINC01363 →	+0.090	+1.958	.004	.006	3	2
BLCA	MTND4LP7 →	+0.137	+4.533	.008	.005	3	2
BLCA	MIR101-2 →	+0.508	+4.396	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 405 associations by consensus.

TUBB4BP4 by HCRTR1 expression — GBM

Explore this box plot interactively →