HCRTR1

Across TCGA patient cohorts, HCRTR1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCRTR1-associated genes across cancer lineages are HER3, NF2, and Annexin-1. Each is linked with HCRTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCRTR1-to-partner and partner-to-HCRTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by HCRTR1-low versus HCRTR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCRTR1→partner) and Y-score (partner→HCRTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	+0.585	+2.183	<.001	.035	3	1
UCEC	NF2 →	+0.375	+3.321	<.001	.010	3	1
UCEC	Annexin-1 →	+0.844	+2.827	.002	.035	3	1
UCEC	TAZ →	+0.171	+2.817	.021	.036	3	1
UCEC	Bcl-xL →	+0.214	+3.000	.010	.036	2	2
UCEC	4E-BP1 →	+0.367	+2.837	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

HER3 by HCRTR1 expression — UCEC

Explore this box plot interactively →