HCRTR1

Across TCGA cell cohorts, HCRTR1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible HCRTR1-associated genes across cancer lineages are OR4F5, MMD2, and PRR23C. Each is linked with HCRTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCRTR1-to-partner and partner-to-HCRTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F5 grouped by HCRTR1-low versus HCRTR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCRTR1→partner) and Y-score (partner→HCRTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F5 →	+0.036	+4.930	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR4F5 by HCRTR1 expression — LARGE_INTESTINE

Explore this box plot interactively →