HCN2

Across TCGA patient cohorts, HCN2 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,893 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCN2-associated proteins across cancer lineages are NAB2_S162, AGT, and SPP1_S280. Each is linked with HCN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCN2-to-partner and partner-to-HCN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCN2 versus NAB2_S162 in LSCC, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN2→partner) and Y-score (partner→HCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NAB2_S162 →	+0.441	+0.268	.005	.003	3	3
GBM	AGT →	+0.377	+1.111	.005	<.001	3	3
LUAD	SPP1_S280 →	+0.963	+0.379	<.001	.002	3	3
UCEC	VSNL1 →	+1.460	+0.471	.001	.006	3	3
LUAD	WWP2 →	-0.301	-0.408	<.001	<.001	3	3
PDAC	ZDHHC13 →	-0.365	-0.320	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,893 associations by consensus.

HCN2 vs NAB2_S162 — LSCC

Explore this scatter interactively →