HCN2

Across TCGA patient cohorts, HCN2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,801 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCN2-associated genes across cancer lineages are MFNG, GRK3, and PIK3IP1. Each is linked with HCN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCN2-to-partner and partner-to-HCN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCN2 versus MFNG in GBM, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN2→partner) and Y-score (partner→HCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MFNG →	+0.479	+0.453	<.001	<.001	3	1
GBM	GRK3 →	+0.542	+0.602	<.001	<.001	3	1
GBM	PIK3IP1 →	+0.731	+0.567	<.001	<.001	3	1
GBM	CRYBB1 →	+0.833	+0.812	<.001	<.001	3	1
GBM	SOX10 →	+1.676	+0.807	<.001	<.001	3	1
GBM	SLC16A8 →	+0.632	+0.727	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,801 associations by consensus.

HCN2 vs MFNG — GBM

Explore this scatter interactively →