HCN2

Across TCGA patient cohorts, HCN2 mutation is significantly associated with the RNA expression of many other genes, with 1,239 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCN2-associated genes across cancer lineages are ATAD3A, MIR7702, and SEC13. Each is linked with HCN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCN2-to-partner and partner-to-HCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATAD3A grouped by HCN2-low versus HCN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN2→partner) and Y-score (partner→HCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATAD3A →	+0.578	+3.247	<.001	<.001	3	3
UCEC	MIR7702 →	+0.171	+3.812	<.001	.008	3	3
UCEC	SEC13 →	+0.420	+2.087	<.001	.006	3	3
SKCM	RNU6-9 →	+0.413	+2.254	<.001	.005	3	2
SKCM	RNA5SP38 →	+0.181	+3.130	<.001	.006	3	2
CESC	RPL31P20 →	+0.130	+4.269	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,239 associations by consensus.

ATAD3A by HCN2 expression — UCEC

Explore this box plot interactively →