HCN2

Across TCGA cell cohorts, HCN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,292 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HCN2-associated GO terms across cancer lineages are Cellular response to aldosterone, Response to aldosterone, and Positive regulation of sodium ion transport. Each is linked with HCN2 in more than 12 cancer types. Because this analysis shows association rather than direction, both HCN2-to-partner and partner-to-HCN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to aldosterone grouped by HCN2-low versus HCN2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN2→partner) and Y-score (partner→HCN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Cellular response to aldosterone →	-0.380	-1.243	.001	.004	2	13
LUNG_NSCLC_LUAD	Response to aldosterone →	-0.137	-0.931	<.001	.008	3	10
STOMACH	Positive regulation of sodium ion transport →	-0.224	-1.282	.001	.007	3	9
PANCREAS	Potassium ion import across plasma membrane →	-0.252	-1.356	<.001	<.001	3	9
LARGE_INTESTINE	Negative regulation of Rac protein signal transduction →	+0.734	+0.465	<.001	.004	3	9
LUNG_NSCLC_LUSC	Cell communication involved in cardiac conduction →	-0.191	-1.115	.004	.005	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,292 associations by consensus.

Cellular response to aldosterone by HCN2 expression — OESOPHAGUS

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