HCN1

Across TCGA pan-cancer cohorts, HCN1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated HCN1 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HCN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HCN1 expression acts as an unfavorable survival marker.

COAD, BRCA, and ESCA are the cancer types where HCN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	IV	0.217	0.671	.002	19	view →
BRCA	OS	Median	III,IV	0.313	0.834	.006	12	view →
ESCA	DFS	Median	III,IV	0.167	0.453	.017	9	view →
MESO	DFS	Median	All	0.098	0.366	.039	6	view →
PAAD	DFS	Median	All	0.100	0.505	.004	6	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
HNSC	OS	Median	All	0.389	0.714	.002	5	view →
PRAD	DFS	Median	All	0.189	0.776	.021	4	view →
GBM	DFS	Median	All	0.062	0.244	.003	3	view →
LUAD	DFS	Median	All	0.720	0.820	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HCN1–COAD (OS)

Open the COAD breakdown →