HCK

Across TCGA pan-cancer cohorts, HCK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HCK data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HCK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HCK expression acts as an unfavorable survival marker.

COAD, CCRCC, and PDAC are the cancer types where HCK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	0.715	1.000	.014	96	view →
CCRCC	OS	Quartile	All	0.472	1.000	.008	27	view →
PDAC	OS	Quartile	II,III,IV	0.645	1.000	.002	9	view →
GBM	OS	Quartile	All	0.252	0.578	.012	4	view →
LUAD	OS	Median	II,III,IV	0.863	0.999	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HCK–COAD (DFS)

Open the COAD breakdown →