HCK

Across TCGA pan-cancer cohorts, HCK RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HCK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HCK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HCK is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and LUAD are the cancer types where HCK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HCK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.326	<.001	12	view →
KIRP	Male	All	+1.564	<.001	9	view →
LUAD	Male	II,III,IV	−1.563	<.001	9	view →
HNSC	All	II,III,IV	+0.874	<.001	9	view →
THCA	Male	II,III,IV	+1.487	.001	8	view →
LUSC	Male	II,III,IV	−1.511	<.001	7	view →
STAD	All	II,III,IV	+1.062	.001	7	view →
COAD	All	All	−0.548	.001	7	view →
BRCA	Female	All	+0.392	.001	4	view →
PAAD	All	All	−1.824	.032	2	view →
READ	Female	All	−1.020	.035	1	view →
LIHC	Male	All	−0.521	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HCK–KIRC

Open the KIRC breakdown →