HCK

Across TCGA patient cohorts, HCK RNA expression is significantly associated with the protein abundance of many other proteins, with 18,626 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCK-associated proteins across cancer lineages are CYBB, DOCK8, and DOK2. Each is linked with HCK in more than 9 cancer types. Because this analysis shows association rather than direction, both HCK-to-partner and partner-to-HCK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCK versus CYBB in UCEC, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HCK→partner) and Y-score (partner→HCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYBB →	+1.210	+1.266	<.001	<.001	3	10
GBM	DOCK8 →	+0.727	+1.350	<.001	<.001	3	10
HNSC	DOK2 →	+0.610	+1.146	<.001	<.001	3	10
GBM	AIF1 →	+1.093	+1.373	<.001	<.001	3	10
GBM	FMNL1 →	+0.788	+1.324	<.001	<.001	3	10
GBM	PTPN6 →	+0.806	+1.229	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,626 associations by consensus.

HCK vs CYBB — UCEC

Explore this scatter interactively →