HCK

Across TCGA patient cohorts, HCK protein abundance is significantly associated with the RNA expression of many other genes, with 20,267 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCK-associated genes across cancer lineages are CYTH4, SIRPB1, and TLR8. Each is linked with HCK in more than 9 cancer types. Because this analysis shows association rather than direction, both HCK-to-partner and partner-to-HCK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCK versus CYTH4 in GBM, with a Pearson correlation of 0.88.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCK→partner) and Y-score (partner→HCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+1.231	+0.876	<.001	<.001	3	10
UCEC	SIRPB1 →	+0.727	+0.562	<.001	<.001	3	10
GBM	TLR8 →	+1.282	+0.871	<.001	<.001	3	10
OV	TNFSF13B →	+0.943	+0.540	<.001	<.001	3	10
GBM	IL21R →	+1.263	+0.802	<.001	<.001	3	10
GBM	LILRB1 →	+1.135	+0.908	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,267 associations by consensus.

HCK vs CYTH4 — GBM

Explore this scatter interactively →