HCK

Across TCGA patient cohorts, HCK mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCK-associated genes across cancer lineages are ERK2, 4E-BP1, and Di-Ras3. Each is linked with HCK in more than 2 cancer types. Because this analysis shows association rather than direction, both HCK-to-partner and partner-to-HCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by HCK-low versus HCK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCK→partner) and Y-score (partner→HCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.269	+2.415	<.001	.003	3	3
UCEC	4E-BP1 →	+0.358	+1.906	.001	.016	3	3
UCEC	Di-Ras3 →	-0.146	-3.156	.014	.018	3	3
UCEC	GAPDH →	+0.589	+3.459	.006	.005	3	2
UCEC	MEK1_p_S217_S221 →	-0.434	-3.087	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.233	-3.680	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ERK2 by HCK expression — UCEC

Explore this box plot interactively →