HCK

Across TCGA cell cohorts, HCK RNA expression is significantly associated with the go_rna of many other GO terms, with 2,511 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HCK-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Cytoplasmic translation, and Regulation of translational initiation. Each is linked with HCK in more than 8 cancer types. Because this analysis shows association rather than direction, both HCK-to-partner and partner-to-HCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by HCK-low versus HCK-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCK→partner) and Y-score (partner→HCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.159	+1.518	.002	.006	2	9
OESOPHAGUS	Cytoplasmic translation →	+0.116	+1.406	<.001	.003	2	9
STOMACH	Regulation of translational initiation →	+0.093	+0.380	<.001	.005	3	8
OESOPHAGUS	Mitochondrial electron transport, cytochrome c to oxygen →	+0.127	+1.887	.001	.001	3	8
LUNG_NSCLC_LUAD	Heterochromatin formation →	+0.034	+0.096	<.001	.002	3	7
STOMACH	Regulation of G1/S transition of mitotic cell cycle →	+0.094	+0.377	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,511 associations by consensus.

Negative regulation of myoblast fusion by HCK expression — OESOPHAGUS

Explore this box plot interactively →