HCK

Across TCGA cell cohorts, HCK mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCK-associated genes across cancer lineages are FCAR, OR9G4, and OR1D2. Each is linked with HCK in more than 1 cancer types. Because this analysis shows association rather than direction, both HCK-to-partner and partner-to-HCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCAR grouped by HCK-low versus HCK-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCK→partner) and Y-score (partner→HCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FCAR →	+0.557	+4.269	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR9G4 →	+0.039	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1D2 →	+0.026	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1P1 →	+0.058	+4.887	<.001	.009	3	1
LARGE_INTESTINE	ELOVL4 →	+0.584	+3.443	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

FCAR by HCK expression — LUNG_SCLC

Explore this box plot interactively →