HCG4

Across TCGA patient cohorts, HCG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,163 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible HCG4-associated GO terms across cancer lineages are MDA-5 signaling pathway, Carbohydrate derivative catabolic process, and Golgi vesicle transport. Each is linked with HCG4 in more than 22 cancer types. Because this analysis shows association rather than direction, both HCG4-to-partner and partner-to-HCG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDA-5 signaling pathway grouped by HCG4-low versus HCG4-high in CHOL.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCG4→partner) and Y-score (partner→HCG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	MDA-5 signaling pathway →	+0.118	+1.517	<.001	<.001	3	23
THYM	Carbohydrate derivative catabolic process →	+0.027	+1.071	<.001	<.001	3	20
THYM	Golgi vesicle transport →	+0.051	+0.985	<.001	<.001	3	20
THYM	Response to type I interferon →	+0.048	+1.023	<.001	<.001	3	19
LAML	Interleukin-17A-mediated signaling pathway →	+0.048	+0.442	.001	<.001	1	21
THYM	Post-Golgi vesicle-mediated transport →	+0.060	+1.013	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,163 associations by consensus.

MDA-5 signaling pathway by HCG4 expression — CHOL

Explore this box plot interactively →