HCG4

Across TCGA pan-cancer cohorts, HCG4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HCG4 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HCG4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HCG4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, LUSC, and GBM are the cancer types where HCG4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.705	0.555	.001	28	view →
LUSC	DFS	Tertile	III,IV	0.530	0.785	.007	24	view →
GBM	OS	Tertile	All	0.307	0.596	.003	21	view →
UCS	DFS	Tertile	II,III,IV	0.568	0.158	.009	18	view →
DLBC	OS	Median	All	1.000	0.796	.004	17	view →
BRCA	OS	Tertile	All	0.655	0.489	.016	16	view →
KICH	DFS	Tertile	III,IV	0.344	0.877	.009	12	view →
LAML	DFS	Median	All	0.486	0.642	.017	12	view →
STAD	OS	Median	III,IV	0.567	0.692	.021	11	view →
SARC	DFS	Quartile	All	0.741	0.400	.001	11	view →
COAD	OS	Median	II,III,IV	0.871	0.715	.016	10	view →
MESO	DFS	Tertile	II,III,IV	0.384	0.686	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HCG4–KIRC (OS)

Open the KIRC breakdown →