HCFC1

Across TCGA cell cohorts, HCFC1 mutation is significantly associated with the RNA expression of many other genes, with 885 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCFC1-associated genes across cancer lineages are SHOX, CDX4, and LCE1F. Each is linked with HCFC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCFC1-to-partner and partner-to-HCFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHOX grouped by HCFC1-low versus HCFC1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCFC1→partner) and Y-score (partner→HCFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SHOX →	+0.046	+3.906	<.001	.009	3	2
BREAST	CDX4 →	+0.008	+4.196	<.001	.006	3	2
CNS	LCE1F →	+0.345	+3.459	<.001	.006	3	2
BLOOD_Leukemia	FAM149A →	+0.886	+3.961	<.001	<.001	3	2
BLOOD_Leukemia	C12orf57 →	+1.072	+3.367	<.001	.002	3	2
BLOOD_Leukemia	GCH1 →	+1.236	+2.614	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 885 associations by consensus.

SHOX by HCFC1 expression — BLOOD_Myeloma

Explore this box plot interactively →